Estudios sobre Células madre

Most advanced Stem cells and Stem cell therapy. Stem Cells Colombia, Células madre Medellín Colombia

Algunas referencias bibliográficas e investigación científica con estudios sobre células madre y exosomas derivados de células madre y sus aplicaciones para tratar diferentes patologías. 

Presentamos algunos estudios sobre células madre dirigidos a conocer los mecanismos de acción en el sistema inmune y en células y tejidos del cuerpo tanto en laboratorio como en aplicaciones terapeuticas.

Los estudios presentados a continuación estan escritos en español e inglés.

Stem Cell provider with advanced stem cell research and development.

Scientific Literature on Stem cell Research in english:


1. Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011;480:480–489. doi: 10.1038/nature10673. [PMC free article] [PubMed] [CrossRef[]
2. Ancans J. Cell therapy medicinal product regulatory framework in Europe and its application for MSC-based therapy development. Front. Immunol. 2012;3:253. doi: 10.3389/fimmu.2012.00253. [PMC free article] [PubMed] [CrossRef[]
3. Yin JQ, Zhu J, Ankrum JA. Manufacturing of primed mesenchymal stromal cells for therapy. Nat. Biomed. Eng. 2019;3:90–104. doi: 10.1038/s41551-018-0325-8. [PubMed] [CrossRef[]
4. O’Brien T, Barry FP. Stem cell therapy and regenerative medicine. Mayo Clin. Proc. 2009;84:859–861. doi: 10.4065/84.10.859. [PMC free article] [PubMed] [CrossRef[]
5. Mousaei Ghasroldasht, M., Seok, J., Park, H. S., Liakath Ali, F. B. & Al-Hendy, A. Stem cell therapy: from idea to clinical practice. Int. J. Mol. Sci23, 2850 (2022). [PMC free article] [PubMed]
6. Kuriyan AE, et al. Vision loss after intravitreal injection of autologous “stem cells” for AMD. N. Engl. J. Med. 2017;376:1047–1053. doi: 10.1056/NEJMoa1609583. [PMC free article] [PubMed] [CrossRef[]
7. Biehl JK, Russell B. Introduction to stem cell therapy. J. Cardiovasc. Nurs. 2009;24:98–103. doi: 10.1097/JCN.0b013e318197a6a5. [PMC free article] [PubMed] [CrossRef[]
8. Srijaya TC, Ramasamy TS, Kasim NH. Advancing stem cell therapy from bench to bedside: lessons from drug therapies. J. Transl. Med. 2014;12:243. doi: 10.1186/s12967-014-0243-9. [PMC free article] [PubMed] [CrossRef[]
9. Ramalho-Santos M, Willenbring H. On the origin of the term “stem cell” Cell Stem Cell. 2007;1:35–38. doi: 10.1016/j.stem.2007.05.013. [PubMed] [CrossRef[]
10. Konstantinov IE. In search of Alexander A. Maximow: the man behind the unitarian theory of hematopoiesis. Perspect. Biol. Med. 2000;43:269–276. doi: 10.1353/pbm.2000.0006. [PubMed] [CrossRef[]
11. Droscher A. Images of cell trees, cell lines, and cell fates: the legacy of Ernst Haeckel and August Weismann in stem cell research. Hist. Philos. Life Sci. 2014;36:157–186. doi: 10.1007/s40656-014-0028-8. [PubMed] [CrossRef[]
12. Jansen J. The first successful allogeneic bone-marrow transplant: Georges Mathe. Transfus. Med. Rev. 2005;19:246–248. doi: 10.1016/j.tmrv.2005.02.006. [PubMed] [CrossRef[]
13. Blume KG, Weissman ILE. Donnall Thomas (1920-2012) Proc. Natl Acad. Sci. USA. 2012;109:20777–20778. doi: 10.1073/pnas.1218913109. [PMC free article] [PubMed] [CrossRef[]
14. Cheng M. Hartmann Stahelin (1925-2011) and the contested history of cyclosporin A. Clin. Transpl. 2013;27:326–329. doi: 10.1111/ctr.12072. [PubMed] [CrossRef[]
15. Thomas ED, et al. Aplastic anaemia treated by marrow transplantation. Lancet. 1972;1:284–289. doi: 10.1016/S0140-6736(72)90292-9. [PubMed] [CrossRef[]
16. Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet. 1987;20:263–272. [PubMed[]
17. Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970;3:393–403. [PubMed[]
18. Caplan AI. Mesenchymal stem cells. J. Orthop. Res. 1991;9:641–650. doi: 10.1002/jor.1100090504. [PubMed] [CrossRef[]
19. Bolli R, Tang XL, Guo Y, Li Q. After the storm: an objective appraisal of the efficacy of c-kit+ cardiac progenitor cells in preclinical models of heart disease. Can. J. Physiol. Pharm. 2021;99:129–139. doi: 10.1139/cjpp-2020-0406. [PMC free article] [PubMed] [CrossRef[]
20. Liu C, Han D, Liang P, Li Y, Cao F. The current dilemma and breakthrough of stem cell therapy in ischemic heart disease. Front. Cell Dev. Biol. 2021;9:636136. doi: 10.3389/fcell.2021.636136. [PMC free article] [PubMed] [CrossRef[]
21. Zhang J, et al. Basic and translational research in cardiac repair and regeneration: JACC state-of-the-art review. J. Am. Coll. Cardiol. 2021;78:2092–2105. doi: 10.1016/j.jacc.2021.09.019. [PMC free article] [PubMed] [CrossRef[]
22. Gyongyosi M, Wojakowski W, Navarese EP, Moye LA, Investigators A. Meta-analyses of human cell-based cardiac regeneration therapies: controversies in meta-analyses results on cardiac cell-based regenerative studies. Circ. Res. 2016;118:1254–1263. doi: 10.1161/CIRCRESAHA.115.307347. [PMC free article] [PubMed] [CrossRef[]
23. Okamoto R, Matsumoto T, Watanabe M. Regeneration of the intestinal epithelia: regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells. Hum. Cell. 2006;19:71–75. doi: 10.1111/j.1749-0774.2006.00010.x. [PubMed] [CrossRef[]
24. Gehart H, Clevers H. Tales from the crypt: new insights into intestinal stem cells. Nat. Rev. Gastroenterol. Hepatol. 2019;16:19–34. doi: 10.1038/s41575-018-0081-y. [PubMed] [CrossRef[]
25. Santos AJM, Lo YH, Mah AT, Kuo CJ. The intestinal stem cell niche: homeostasis and adaptations. Trends Cell Biol. 2018;28:1062–1078. doi: 10.1016/j.tcb.2018.08.001. [PMC free article] [PubMed] [CrossRef[]
26. Roda G, et al. Crohn’s disease. Nat. Rev. Dis. Prim. 2020;6:22. doi: 10.1038/s41572-020-0156-2. [PubMed] [CrossRef[]
27. Kobayashi T, et al. Ulcerative colitis. Nat. Rev. Dis. Prim. 2020;6:74. doi: 10.1038/s41572-020-0205-x. [PubMed] [CrossRef[]
28. Gratwohl A, et al. Autologous hematopoietic stem cell transplantation for autoimmune diseases. Bone Marrow Transpl. 2005;35:869–879. doi: 10.1038/sj.bmt.1704892. [PubMed] [CrossRef[]
29. Kashyap A, Forman SJ. Autologous bone marrow transplantation for non-Hodgkin’s lymphoma resulting in long-term remission of coincidental Crohn’s disease. Br. J. Haematol. 1998;103:651–652. doi: 10.1046/j.1365-2141.1998.01059.x. [PubMed] [CrossRef[]
30. Hurley JM, Lee SG, Andrews RE, Jr., Klowden MJ, Bulla LA., Jr. Separation of the cytolytic and mosquitocidal proteins of Bacillus thuringiensis subsp. israelensis. Biochem Biophys. Res. Commun. 1985;126:961–965. doi: 10.1016/0006-291X(85)90279-7. [PubMed] [CrossRef[]
31. Oyama Y, et al. Autologous hematopoietic stem cell transplantation in patients with refractory Crohn’s disease. Gastroenterology. 2005;128:552–563. doi: 10.1053/j.gastro.2004.11.051. [PubMed] [CrossRef[]
32. Burt RK, et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-up. Blood. 2010;116:6123–6132. doi: 10.1182/blood-2010-06-292391. [PubMed] [CrossRef[]
33. Hasselblatt P, et al. Remission of refractory Crohn’s disease by high-dose cyclophosphamide and autologous peripheral blood stem cell transplantation. Aliment Pharm. Ther. 2012;36:725–735. doi: 10.1111/apt.12032. [PubMed] [CrossRef[]
34. Hawkey CJ, et al. Autologous hematopoetic stem cell transplantation for refractory Crohn disease: a randomized clinical trial. J. Am. Med. Assoc. 2015;314:2524–2534. doi: 10.1001/jama.2015.16700. [PubMed] [CrossRef[]
35. Lindsay JO, et al. Autologous stem-cell transplantation in treatment-refractory Crohn’s disease: an analysis of pooled data from the ASTIC trial. Lancet Gastroenterol. Hepatol. 2017;2:399–406. doi: 10.1016/S2468-1253(17)30056-0. [PubMed] [CrossRef[]
36. Wang R, et al. Stem cell therapy for Crohn’s disease: systematic review and meta-analysis of preclinical and clinical studies. Stem Cell Res Ther. 2021;12:463. doi: 10.1186/s13287-021-02533-0. [PMC free article] [PubMed] [CrossRef[]
37. Hawkey CJ. Hematopoietic stem cell transplantation in Crohn’s disease: state-of-the-art treatment. Dig. Dis. 2017;35:107–114. doi: 10.1159/000449090. [PubMed] [CrossRef[]
38. Si-Tayeb K, Lemaigre FP, Duncan SA. Organogenesis and development of the liver. Dev. Cell. 2010;18:175–189. doi: 10.1016/j.devcel.2010.01.011. [PubMed] [CrossRef[]
39. Xue R, et al. Clinical performance of stem cell therapy in patients with acute-on-chronic liver failure: a systematic review and meta-analysis. J. Transl. Med. 2018;16:126. doi: 10.1186/s12967-018-1464-0. [PMC free article] [